Characterization of DNA Damage Repair in Myogenic Precursors

Say Tar Goh : Molecular and Cell Biology

Mentor: Professor Irina Conboy, Bioengineering

Muscle stem cells, or satellite cells, are located in muscle fibers and are responsible for muscle repair in mammals throughout adult life. As individuals age, the capability of satellite cells to repair muscle dramatically declines. The loss of such capabilities can be related to the host environment, in that extracellular niches provided by old hosts hamper their ability to regenerate muscle, regardless of the origin of the cells themselves. Say Tar hypothesizes that this can, at least in part, be linked to their reduced ability to repair DNA in an unfavorable extracellular environment generated by the host. He will try to draw this potential link by characterizing DNA damage repair ability in muscle stem cells, subjecting them to various culture environments, derived from differently aged animals and different stress conditions