Positional Cloning of the Grinch Mutation in Xenopus Tropicalis

Dang Lam : Molecular and Cell Biology

Mentor: Professor Richard Harland, Molecular and Cell Biology

Under the guidance of Dr. Richard Harland and two postdoctoral fellows, Dr. Timothy Grammer and Dr. Mustafa Khokha, Dang will study the novel grinch mutation that affects the lymphatic system of the frog Xenopus tropicalis. Like humans, frogs have a lymphatic system which drains fluids from tissues back to the bloodstream. The lymphatic system influences the course of many human diseases, from lymphedema to tumor metastasis; and currently little is known about the molecular basis of lymphatic development. Dang’s efforts will ultimately result in the characterization and identification of the mutated gene, which will contribute to our understanding of the amphibian lymphatic system and possibly that of humans.