Characterization of Fine Genetic Regulatory Mechanisms of a Bacterial sRNA in the Virulence of a Foodborne Pathogen Salmonella Typhimurium
Salmonella is the leading source of food-borne diseases in the United States. Infection by Salmonella Typhimurium causesdiseases ranging from self-limiting gastroenteritis to life-threatening systemic infection, provoking around 1.3 billion cases every year worldwide. Moreover, no vaccine to prevent salmonellosis exists. Recently, 19 small noncoding bacterial RNAs (sRNAs) located in salmonella SPIs were discovered, of which IsrC is one of the newest forms. Bacterial sRNAs regulate the expression of their target genes in pathogenesis, essentially contributing to bacterial invasiveness. My research will focus on the interaction between IsrC and its predicted target, HilE, a global negative regulator of salmonella virulence genes. This research seeks to further clarify the role of sRNAs in the molecular pathogenesis of salmonella virulence as well as increase the possibility of developing new strategies against bacterial infection, thus lowering salmonella infection rates.
- Major: Molecular and Cell Biology
- Mentor: Fenyong Liu, Public Health